PTPRZ1 and ALK

Number of citations of the paper that reports this interaction (PubMedID 17681947)
50

Data Source:
HPRD (in vitro, in vivo)

		PTPRZ1	ALK
Description		protein tyrosine phosphatase receptor type Z1	ALK receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane Synapse Perineuronal Net	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Axonogenesis Central Nervous System Development Learning Or Memory Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Phosphorylation Peptidyl-tyrosine Phosphorylation Hippocampus Development Adult Behavior Positive Regulation Of Kinase Activity Swimming Behavior NIK/NF-kappaB Signaling Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways		Signaling by ALK Other interleukin signaling	Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026- resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer
Drugs			ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases
GWAS		Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)	Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)
Interacting Genes		16 interacting genes: AASS ADD2 ALK ARHGAP35 BMP1 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B NMB PTN PTPRF TNR	28 interacting genes: BIRC6 CLNS1A DLG2 DNMT3A DUSP19 ERBB2 HADHB HMGB1 IKBKG IRS1 JAK3 MDK MSH2 NLRC4 NPM1 PIK3R1 PLCG1 PPM1A PTN PTPRZ1 RASA1 SHC1 SHC3 SMC1A TNFRSF8 TSPAN16 TTC19 ZC3HC1
Entrez ID		5803	238
HPRD ID		01481	00104
Ensembl ID		ENSG00000106278	ENSG00000171094
Uniprot IDs		B4DFE7 P23471	B6D4Y2 Q9UM73
PDB IDs		3JXF 3S97 5AWX 5H08	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7JY4 7JYR 7JYS 7JYT
Enriched GO Terms of Interacting Partners?
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