PAK5 and CRBN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PAK5	CRBN
Description		p21 (RAC1) activated kinase 5	cereblon
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Synapse	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle	Potential therapeutics for SARS
Drugs		Fostamatinib	Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91
Entrez ID		57144	51185
HPRD ID		06423	16750
Ensembl ID		ENSG00000101349	ENSG00000113851
Uniprot IDs		B0AZM9 Q9P286	Q96SW2
PDB IDs		2F57	4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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