CRBN and SUV39H1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		CRBN	SUV39H1
Description		cereblon	SUV39H1 histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Chromatin Organization RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways		Potential therapeutics for SARS	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DDB1 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9
Entrez ID		51185	6839
HPRD ID		16750	02221
Ensembl ID		ENSG00000113851	ENSG00000101945
Uniprot IDs		Q96SW2	O43463
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV	3MTS
Enriched GO Terms of Interacting Partners?
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