CRBN and OSR2

Number of citations of the paper that reports this interaction (PubMedID 30385546)
64

Data Source:
BioGRID (pull down)

		CRBN	OSR2
Description		cereblon	odd-skipped related transciption factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	Protein Binding Transmembrane Transporter Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Large Conductance Calcium-activated Potassium Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Metanephros Development Mesonephros Development Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Embryo Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Bone Mineralization Osteoblast Proliferation Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Skeletal Limb Joint Morphogenesis Middle Ear Morphogenesis Odontogenesis Embryonic Digit Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Embryonic Skeletal Joint Morphogenesis Head Development Bone Morphogenesis Eyelid Development In Camera-type Eye Embryonic Skeletal Joint Development
Pathways		Potential therapeutics for SARS
Drugs		Lenalidomide Thalidomide Pomalidomide
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)
Interacting Genes		38 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CUL4B CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	4 interacting genes: CRBN KRTAP6-1 LIMS1 PSMA3
Entrez ID		51185	116039
HPRD ID		16750	17806
Ensembl ID		ENSG00000113851	ENSG00000164920
Uniprot IDs		Q96SW2	Q8N2R0
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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