PAK5 and ARMC7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PAK5	ARMC7
Description		p21 (RAC1) activated kinase 5	armadillo repeat containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Signal Transduction Learning Memory Locomotory Behavior Cell Population Proliferation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Bipolar disorder ( 31043756)
Interacting Genes		34 interacting genes: ARHGEF19 ARMC7 ATPAF2 BAD CARD9 CATSPER1 CCDC57 CCNG1 CDC42 CRBN CSNK1D DDX6 DNPEP EMD ENKD1 EXOSC1 FHL3 GCC1 INKA1 LENG1 LNX1 LZTS2 MYO15B NTAQ1 PDLIM7 PRPF31 PSMF1 PTPN21 RAC1 RHOJ SORBS3 TSGA10 TUBGCP4 UXT	72 interacting genes: ABI2 ABI3 APP C11orf1 C2orf88 CBY2 CCDC28B CCDC33 CDC42EP1 CHCHD3 CPSF6 CPSF7 DISC1 DPEP2NB DTX2 EFHC2 ESS2 GATA1 GIGYF1 HGS HOXA1 IKZF1 IKZF3 INCA1 KCTD13 KRT31 KRT34 KRT39 KRT40 KRT75 KRTAP13-1 KRTAP19-7 KRTAP6-3 LZTS2 MDFI NME4 PAK5 PIMREG PLEKHG4 PNMA6A RBM48 REL RRP7A RUNDC3A SAXO1 SEPTIN14 SHISA6 SLAIN1 SPATC1L SPG21 SYF2 TASOR2 TCF4 TEX45 TFIP11 TNFAIP1 TNNI1 TRIB3 TRIM27 TRIM42 TRIM54 USP54 VIM VPS37D YPEL3 ZBTB8A ZC2HC1C ZMAT5 ZNF140 ZNF426 ZNF669 ZNF764
Entrez ID		57144	79637
HPRD ID		06423	08649
Ensembl ID		ENSG00000101349	ENSG00000125449
Uniprot IDs		B0AZM9 Q9P286	J3KST7 J3KTE5 Q9H6L4
PDB IDs		2F57
Enriched GO Terms of Interacting Partners?
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