SMCO4 and SPINT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMCO4	SPINT1
Description		single-pass membrane protein with coiled-coil domains 4	serine peptidase inhibitor, Kunitz type 1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Biological_process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)	Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		60 interacting genes: AQP6 ATP2A2 BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC16A2 SLC18A1 SLC35C2 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		56935	6692
HPRD ID		17008	05494
Ensembl ID		ENSG00000166002	ENSG00000166145
Uniprot IDs		A0A024R3A3 Q9NRQ5	O43278
PDB IDs			1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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