PBK and ARAF

Number of citations of the paper that reports this interaction (PubMedID 12620389)
13

Data Source:
HPRD (in vitro)

		PBK	ARAF
Description		PDZ binding kinase	A-Raf proto-oncogene, serine/threonine kinase
Image
GO Annotations	Cellular Component	Nucleus	Cellular_component Mitochondrion Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Negative Regulation Of Inflammatory Response	MAPK Cascade Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process
Pathways			RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs			ATP
Diseases
GWAS
Interacting Genes		20 interacting genes: ARAF CCNB1 CDK1 CEP126 DLG1 GPRASP1 GPS2 H2AX LNX1 MCRS1 PTEN RAF1 SH2D4A SMAD4 TERT TP53 TRIM37 ZBTB26 ZFP64 ZNF526	58 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG
Entrez ID		55872	369
HPRD ID		17822	02405
Ensembl ID		ENSG00000168078	ENSG00000078061
Uniprot IDs		Q96KB5 V9HWH0	A0A024R178 P10398 Q96II5
PDB IDs		5J0A	1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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