NLRP2 and CARD8

Number of citations of the paper that reports this interaction (PubMedID 15030775)
535

Data Source:
HPRD (in vivo)

		NLRP2	CARD8
Description		NLR family pyrin domain containing 2	caspase recruitment domain family member 8
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Cytoplasm Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Pyrin Domain Binding	Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Apoptotic Process Inflammatory Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response To Virus Self Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways			Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Venous thromboembolism ( 31420334)
Interacting Genes		4 interacting genes: APP CARD8 FAF1 PYDC2	9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3
Entrez ID		55655	22900
HPRD ID		14805	16425
Ensembl ID		ENSG00000022556	ENSG00000105483
Uniprot IDs		A8K9G6 J3KN39 Q9NX02	A0A024QZD3 Q9Y2G2
PDB IDs			4IKM 6K9F 6XKJ
Enriched GO Terms of Interacting Partners?
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