CARD8 and NLRP2

Number of citations of the paper that reports this interaction (PubMedID 15030775)
535

Data Source:
HPRD (in vivo)

		CARD8	NLRP2
Description		caspase recruitment domain family member 8	NLR family pyrin domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex	Chromosome, Telomeric Region Cytoplasm Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity	Protein Binding ATP Binding Pyrin Domain Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response To Virus Self Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Apoptotic Process Inflammatory Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response
Pathways		Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Venous thromboembolism ( 31420334)
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	4 interacting genes: APP CARD8 FAF1 PYDC2
Entrez ID		22900	55655
HPRD ID		16425	14805
Ensembl ID		ENSG00000105483	ENSG00000022556
Uniprot IDs		A0A024QZD3 Q9Y2G2	A8K9G6 J3KN39 Q9NX02
PDB IDs		4IKM 6K9F 6XKJ
Enriched GO Terms of Interacting Partners?
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