CARD8 and NLRP3

Number of citations of the paper that reports this interaction (PubMedID 15030775)
535

Data Source:
HPRD (in vivo)

		CARD8	NLRP3
Description		caspase recruitment domain family member 8	NLR family pyrin domain containing 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex	Golgi Membrane Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol NLRP3 Inflammasome Complex
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity	Protein Binding ATP Binding Identical Protein Binding Peptidoglycan Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response To Virus Self Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Acute Inflammatory Response Positive Regulation Of Type 2 Immune Response Apoptotic Process Defense Response Inflammatory Response Signal Transduction Detection Of Biotic Stimulus Response To Organic Cyclic Compound Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Response To Ethanol Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Formation of apoptosome Regulation of the apoptosome activity	Metalloprotease DUBs The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels ( 30388399 21300955) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 32888494 27863252) Word reading ( 23738518)
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	9 interacting genes: ATP1B3 CARD8 CUL1 FAF1 FBXL2 PGM1 PYCARD STAMBP VDR
Entrez ID		22900	114548
HPRD ID		16425	05915
Ensembl ID		ENSG00000105483	ENSG00000162711
Uniprot IDs		A0A024QZD3 Q9Y2G2	A0A7I2R3P8 Q96P20
PDB IDs		4IKM 6K9F 6XKJ	2NAQ 3QF2 6NPY
Enriched GO Terms of Interacting Partners?
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