CARD8 and CARD16

Number of citations of the paper that reports this interaction (PubMedID 11821383)
57

Data Source:
HPRD (in vitro, in vivo)

		CARD8	CARD16
Description		caspase recruitment domain family member 8	caspase recruitment domain family member 16
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex	Protein-containing Complex Protease Inhibitor Complex
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Pattern Recognition Receptor Activity Protein Homodimerization Activity CARD Domain Binding Cysteine-type Endopeptidase Activator Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Kinase Binding Identical Protein Binding CARD Domain Binding Caspase Binding
	Biological Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response To Virus Self Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Antiviral Innate Immune Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly	Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Cellular Response To UV-C Inhibition Of Cysteine-type Endopeptidase Activity
Pathways		Formation of apoptosome Regulation of the apoptosome activity
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3	4 interacting genes: CARD17 CARD8 CASP1 RIPK2
Entrez ID		22900	114769
HPRD ID		16425	16740
Ensembl ID		ENSG00000105483	ENSG00000204397
Uniprot IDs		A0A024QZD3 Q9Y2G2	Q5EG05
PDB IDs		4IKM 6K9F 6XKJ
Enriched GO Terms of Interacting Partners?
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