HPF1 and PARP2

Number of citations of the paper that reports this interaction (PubMedID 28190768)
101

Data Source:
BioGRID (pull down)

		HPF1	PARP2
Description		histone PARylation factor 1	poly(ADP-ribose) polymerase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Site Of DNA Damage	Nucleus Nucleoplasm Nucleolus Site Of DNA Damage
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Poly-ADP-D-ribose Binding	DNA Binding Chromatin Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Nucleosome Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation Regulation Of Histone Modification	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Histone Modification Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death
Pathways			POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		16 interacting genes: CLCN3 EIF6 FBXO7 H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HMGA1 HMGB1 HMGN1 HMGN2 HMGN4 PARP1 PARP2	13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1
Entrez ID		54969	10038
HPRD ID		07924	09660
Ensembl ID		ENSG00000056050	ENSG00000129484
Uniprot IDs		Q9NWY4	Q9UGN5
PDB IDs		6M3G 6M3I 6TX2 6TX3 6X0L 6X0M 6X0N	3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?
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