PARP2 and XRCC1

Number of citations of the paper that reports this interaction (PubMedID 11948190)
229

Data Source:
HPRD (in vitro, in vivo)

		PARP2	XRCC1
Description		poly(ADP-ribose) polymerase 2	X-ray repair cross complementing 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Site Of DNA Damage	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex
	Molecular Function	DNA Binding Chromatin Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Nucleosome Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Histone Modification Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death	Single Strand Break Repair Response To Hypoxia Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Xenobiotic Stimulus Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1	20 interacting genes: APEX1 APLF APTX BRCA1 BTRC CHD1L CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB PSMD8 RNF146 TOPORS UBE2I
Entrez ID		10038	7515
HPRD ID		09660	01909
Ensembl ID		ENSG00000129484	ENSG00000073050
Uniprot IDs		Q9UGN5	B2RCY5 P18887 Q59HH7
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2
Enriched GO Terms of Interacting Partners?
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