PARP2 and CENPB

Number of citations of the paper that reports this interaction (PubMedID 12217960)
29

Data Source:
HPRD (in vivo)

		PARP2	CENPB
Description		poly(ADP-ribose) polymerase 2	centromere protein B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Site Of DNA Damage	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Nucleosome Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	DNA Binding Chromatin Binding Satellite DNA Binding Centromeric DNA Binding Sequence-specific DNA Binding
	Biological Process	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Histone Modification Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death
Pathways		POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs		Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS		Menopause (age at onset) ( 26414677)
Interacting Genes		13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1	21 interacting genes: ADRB2 ANXA7 APP CDKN1A CENPW CSNK2B FBXO25 GADD45A GFI1B GSK3B HAND2 LAIR1 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TK1
Entrez ID		10038	1059
HPRD ID		09660	00314
Ensembl ID		ENSG00000129484	ENSG00000125817
Uniprot IDs		Q9UGN5	P07199
PDB IDs		3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N	1BW6 1HLV 1UFI 6KDR
Enriched GO Terms of Interacting Partners?
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