QPCTL and OLFM4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		QPCTL	OLFM4
Description		glutaminyl-peptide cyclotransferase like	olfactomedin 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Metalloexopeptidase Activity Zinc Ion Binding Glutaminyl-peptide Cyclotransferase Activity	Catalytic Activity Structural Molecule Activity Protein Binding Cadherin Binding
	Biological Process	Proteolysis Peptidyl-pyroglutamic Acid Biosynthetic Process, Using Glutaminyl-peptide Cyclotransferase	Cell Adhesion Regulation Of Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of Phagocytosis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Extravasation
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 22344219 26961502 24861553 25673413 20935630) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Fasting glucose ( 34059833) Fruit consumption ( 32066663) Pancreatic beta-cell glucose sensitivity ( 32944759) Subcutaneous adipose tissue ( 22589738) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)	Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 26961502 24861553 25673413 28448500 25953783) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)
Interacting Genes		4 interacting genes: APP C3orf52 OLFM4 PTEN	37 interacting genes: APP AQP2 AQP3 BSCL2 C3 CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PCDH17 PRR20A PRR20B PVR PVRIG QPCTL SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18
Entrez ID		54814	10562
HPRD ID		08612	06580
Ensembl ID		ENSG00000011478	ENSG00000102837
Uniprot IDs		Q9NXS2	A0A024QZ95 Q6UX06
PDB IDs		3PB4 3PB6 3PB7 3PB8 3PB9
Enriched GO Terms of Interacting Partners?
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