OLFM4 and IL11RA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OLFM4	IL11RA
Description		olfactomedin 4	interleukin 11 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Catalytic Activity Structural Molecule Activity Protein Binding Cadherin Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-11 Receptor Activity Protein Binding Cytokine Binding Interleukin-11 Binding
	Biological Process	Cell Adhesion Regulation Of Necrotic Cell Death Regulation Of Apoptotic Process Regulation Of Phagocytosis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Extravasation	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Developmental Process Interleukin-11-mediated Signaling Pathway Head Development
Pathways		Neutrophil degranulation	IL-6-type cytokine receptor ligand interactions
Drugs			Oprelvekin
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 26961502 24861553 25673413 28448500 25953783) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)	Blood protein levels ( 29875488) CTACK levels ( 27989323)
Interacting Genes		37 interacting genes: APP AQP2 AQP3 BSCL2 C3 CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PCDH17 PRR20A PRR20B PVR PVRIG QPCTL SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18	4 interacting genes: CCL21 ELAVL2 IL11 OLFM4
Entrez ID		10562	3590
HPRD ID		06580	02965
Ensembl ID		ENSG00000102837	ENSG00000137070
Uniprot IDs		A0A024QZ95 Q6UX06	Q14626 Q5VZ79
PDB IDs			6O4P
Enriched GO Terms of Interacting Partners?
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