EGLN1 and OS9

Number of citations of the paper that reports this interaction (PubMedID 15721254)
82

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		EGLN1	OS9
Description		egl-9 family hypoxia inducible factor 1	OS9 endoplasmic reticulum lectin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cellular Response To Hypoxia Response To Nitric Oxide	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs		Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Cutaneous mastocytosis ( 32752121) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 32888494 27863252)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		13 interacting genes: DISC1 EPAS1 HIF1A HIF3A HSP90AA1 ING4 KRAS OS9 PLD1 SH3KBP1 SRC VHL ZNF281	28 interacting genes: ACP1 ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FAIM2 FOXM1 GLS2 HIF1A HSP90B1 LINC00839 MEP1B P3H3 PGD PTH RBX1 SCN8A SLC22A1 SMAD2 SNRPD2 SREBF2 TRPV4 UVRAG ZNF512B
Entrez ID		54583	10956
HPRD ID		06971	17804
Ensembl ID		ENSG00000135766	ENSG00000135506
Uniprot IDs		Q9GZT9 R4SCQ0	Q13438
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4	3AIH
Enriched GO Terms of Interacting Partners?
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