OS9 and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 15721254)
82

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		OS9	EGLN3
Description		OS9 endoplasmic reticulum lectin	egl-9 family hypoxia inducible factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protease Binding Protein Binding Carbohydrate Binding	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Cellular Response To Hypoxia
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Roxadustat
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Red blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ACP1 ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FAIM2 FOXM1 GLS2 HIF1A HSP90B1 LINC00839 MEP1B P3H3 PGD PTH RBX1 SCN8A SLC22A1 SMAD2 SNRPD2 SREBF2 TRPV4 UVRAG ZNF512B	39 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655
Entrez ID		10956	112399
HPRD ID		17804	06972
Ensembl ID		ENSG00000135506	ENSG00000129521
Uniprot IDs		Q13438	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs		3AIH
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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