OS9 and P3H3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)

		OS9	P3H3
Description		OS9 endoplasmic reticulum lectin	prolyl 3-hydroxylase 3
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Catalytic Complex
	Molecular Function	Protease Binding Protein Binding Carbohydrate Binding	Iron Ion Binding Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Negative Regulation Of Cell Population Proliferation Peptidyl-lysine Hydroxylation Peptidyl-proline Hydroxylation Collagen Metabolic Process Collagen Biosynthetic Process
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)	Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		28 interacting genes: ACP1 ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FAIM2 FOXM1 GLS2 HIF1A HSP90B1 LINC00839 MEP1B P3H3 PGD PTH RBX1 SCN8A SLC22A1 SMAD2 SNRPD2 SREBF2 TRPV4 UVRAG ZNF512B	7 interacting genes: KRT31 KRTAP1-3 KRTAP12-3 KRTAP9-2 OS9 TRIM55 TRIM63
Entrez ID		10956	10536
HPRD ID		17804	10039
Ensembl ID		ENSG00000135506	ENSG00000110811
Uniprot IDs		Q13438	Q8IVL6
PDB IDs		3AIH
Enriched GO Terms of Interacting Partners?
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