EGLN1 and HIF3A

Number of citations of the paper that reports this interaction (PubMedID 15474027)
33

Data Source:
HPRD (in vitro)

		EGLN1	HIF3A
Description		egl-9 family hypoxia inducible factor 1	hypoxia inducible factor 3 subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Dimerization Activity
	Biological Process	Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cellular Response To Hypoxia Response To Nitric Oxide	Angiogenesis Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation
Drugs		Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Cutaneous mastocytosis ( 32752121) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 32888494 27863252)	Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)
Interacting Genes		13 interacting genes: DISC1 EPAS1 HIF1A HIF3A HSP90AA1 ING4 KRAS OS9 PLD1 SH3KBP1 SRC VHL ZNF281	7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL
Entrez ID		54583	64344
HPRD ID		06971	17104
Ensembl ID		ENSG00000135766	ENSG00000124440
Uniprot IDs		Q9GZT9 R4SCQ0	B2RBI6 H0YDZ5 M0R104 Q9Y2N7
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4	4WN5
Enriched GO Terms of Interacting Partners?
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