POLD2 and POLDIP2

Number of citations of the paper that reports this interaction (PubMedID 12522211)
41

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		POLD2	POLDIP2
Description		DNA polymerase delta 2, accessory subunit	DNA polymerase delta interacting protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Zeta DNA Polymerase Complex DNA Polymerase Complex Delta DNA Polymerase Complex	Nucleus Mitochondrion Mitochondrial Matrix Plasma Membrane Cell-cell Junction Midbody Mitochondrial Nucleoid Mitotic Spindle
	Molecular Function	DNA Binding Protein Binding	DNA Binding Protein Binding
	Biological Process	DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair DNA Biosynthetic Process	Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Focal Adhesion Assembly Mitochondrion Morphogenesis Error-free Translesion Synthesis Mitotic Spindle Assembly Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Actin Filament Binding Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS			Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)
Interacting Genes		19 interacting genes: CCHCR1 CDK2 CDKN1A EP300 ERBB2 KCTD13 LSM6 OGT PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 POLH SOX12 WRN WRNIP1 XRN1	20 interacting genes: AGTRAP ALAS1 APP ASCC2 CHCHD2 CPE DNAAF6 FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1 TMEM97
Entrez ID		5425	26073
HPRD ID		15982	17874
Ensembl ID		ENSG00000106628	ENSG00000004142
Uniprot IDs		A0A087WWF6 P49005	B4DEM9 Q9Y2S7
PDB IDs		3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ	6Z9C
Enriched GO Terms of Interacting Partners?
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