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POLD2

Description DNA polymerase delta 2, accessory subunit
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Zeta DNA Polymerase Complex
  • DNA Polymerase Complex
  • Delta DNA Polymerase Complex
Molecular Function
  • DNA Binding
  • Protein Binding
Biological Process
  • DNA Replication
  • DNA Strand Elongation Involved In DNA Replication
  • DNA Repair
  • DNA Biosynthetic Process
Pathways
  • Recognition of DNA damage by PCNA-containing replication complex
  • Polymerase switching on the C-strand of the telomere
  • Processive synthesis on the C-strand of the telomere
  • Telomere C-strand (Lagging Strand) Synthesis
  • Removal of the Flap Intermediate from the C-strand
  • Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
  • Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
  • PCNA-Dependent Long Patch Base Excision Repair
  • Termination of translesion DNA synthesis
  • HDR through Homologous Recombination (HRR)
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Polymerase switching
  • Removal of the Flap Intermediate
  • Processive synthesis on the lagging strand
Drugs
Diseases
GWAS
Interacting Genes 19 interacting genes: CCHCR1 CDK2 CDKN1A EP300 ERBB2 KCTD13 LSM6 OGT PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 POLH SOX12 WRN WRNIP1 XRN1
Entrez ID 5425
HPRD ID 15982
Ensembl ID ENSG00000106628
Uniprot IDs A0A087WWF6 P49005
PDB IDs 3E0J 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025