POLA1 and PRIM2

Number of citations of the paper that reports this interaction (PubMedID 28757209)
110

Data Source:
BioGRID (pull down)

		POLA1	PRIM2
Description		DNA polymerase alpha 1, catalytic subunit	DNA primase subunit 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleoplasm Alpha DNA Polymerase:primase Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding 4 Iron, 4 Sulfur Cluster Binding	DNA Binding Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	DNA Replication, Synthesis Of RNA Primer Positive Regulation Of DNA Primase Activity
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)
Interacting Genes		25 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A SUMO2 TP53 XRCC5	9 interacting genes: GTF3C6 KDM1A OGT POLA1 POLA2 PRIM1 RECK RUNX2 SUV39H1
Entrez ID		5422	5558
HPRD ID		02416	08900
Ensembl ID		ENSG00000101868	ENSG00000146143
Uniprot IDs		A6NMQ1 P09884	A0A024RD43 P49643
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW
Enriched GO Terms of Interacting Partners?
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