PRIM2 and PRIM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRIM2	PRIM1
Description		DNA primase subunit 2	DNA primase subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Alpha DNA Polymerase:primase Complex	Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding DNA/RNA Hybrid Binding	Magnesium Ion Binding DNA Primase Activity Protein Binding Zinc Ion Binding Ribonucleotide Binding
	Biological Process	DNA Replication, Synthesis Of RNA Primer Positive Regulation Of DNA Primase Activity	DNA Replication, Synthesis Of RNA Primer
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		Chronotype ( 30696823) Coronary artery disease ( 33020668) Daytime nap ( 33568662) Myocardial infarction ( 33532862) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Systemic lupus erythematosus ( 28714469)	Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010)
Interacting Genes		9 interacting genes: GTF3C6 KDM1A OGT POLA1 POLA2 PRIM1 RECK RUNX2 SUV39H1	15 interacting genes: MDC1 MRPL38 NFE2 OGT PDE1B PRIM2 RAB5B RARG RPS26 SENP1 SLC11A2 SLC26A8 STAT6 TP53 YIF1A
Entrez ID		5558	5557
HPRD ID		08900	08899
Ensembl ID		ENSG00000146143	ENSG00000198056
Uniprot IDs		A0A024RD43 P49643	P49642
PDB IDs		3L9Q 3Q36 4BPU 4BPW 4BPX 4RR2 5DQO 5EXR 5F0Q 5F0S 5I7M 6DHW	4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4
Enriched GO Terms of Interacting Partners?
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