POLA1 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 8223465)
47

Data Source:
HPRD (in vivo, in vitro)

		POLA1	POLA2
Description		DNA polymerase alpha 1, catalytic subunit	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding 4 Iron, 4 Sulfur Cluster Binding	Molecular_function DNA Binding Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs		Cladribine Clofarabine Fludarabine Nelarabine	Dacarbazine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Acne (severe) ( 24927181) Hip circumference adjusted for BMI ( 34021172) Serum uric acid levels ( 32514006)
Interacting Genes		25 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A SUMO2 TP53 XRCC5	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		5422	23649
HPRD ID		02416	10160
Ensembl ID		ENSG00000101868	ENSG00000014138
Uniprot IDs		A6NMQ1 P09884	Q14181
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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