POLA1 and CDK2AP1

Number of citations of the paper that reports this interaction (PubMedID 10877824)
13

Data Source:
HPRD (in vivo, in vitro)

		POLA1	CDK2AP1
Description		DNA polymerase alpha 1, catalytic subunit	cyclin dependent kinase 2 associated protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding DNA Polymerase Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Positive Regulation Of Protein Phosphorylation DNA-dependent DNA Replication Cell Cycle
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Schizophrenia ( 25056061 29483656 23974872) Total cholesterol levels ( 29615537) Tourette syndrome ( 30818990)
Interacting Genes		25 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A SUMO2 TP53 XRCC5	13 interacting genes: ATPAF2 CARD9 CCDC136 CDK2 CDK2AP2 GRM3 MRFAP1L1 NTAQ1 PICK1 POLA1 SPG21 USP20 ZNF420
Entrez ID		5422	8099
HPRD ID		02416	03726
Ensembl ID		ENSG00000101868	ENSG00000111328
Uniprot IDs		A6NMQ1 P09884	O14519
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7	2KW6
Enriched GO Terms of Interacting Partners?
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