PHF1 and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PHF1	HSD17B14
Description		PHD finger protein 1	hydroxysteroid 17-beta dehydrogenase 14
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Site Of Double-strand Break	Cytosol
	Molecular Function	Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding Identical Protein Binding Metal Ion Binding Histone Methyltransferase Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation	Steroid Catabolic Process
Pathways		PRC2 methylates histones and DNA	Estrogen biosynthesis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		78 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHB9 BHLHE40 BIRC7 BOLL BRD2 C11orf49 CALCOCO2 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		5252	51171
HPRD ID		04195	16801
Ensembl ID		ENSG00000112511	ENSG00000087076
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	A0A140VJH8 Q9BPX1
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI
Enriched GO Terms of Interacting Partners?
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