MAP3K20 and IGHM

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		MAP3K20	IGHM
Description		mitogen-activated protein kinase kinase kinase 20	immunoglobulin heavy constant mu
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Magnesium Ion Binding RNA Binding MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Single-stranded DNA Binding Antigen Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding
	Biological Process	DNA Damage Checkpoint Signaling Protein Phosphorylation Cytoskeleton Organization Cell Cycle JNK Cascade Cell Death Cell Differentiation P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Regulation Of Cell Cycle Limb Development Cellular Response To Gamma Radiation Positive Regulation Of Mitotic DNA Damage Checkpoint	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation
Pathways
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Haemorrhoidal disease ( 33888516)	Systemic sclerosis ( 33069728)
Interacting Genes		32 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP1 ZFP2 ZNF33A ZNF35 ZNF567 ZNF593 ZNF660 ZNF71 ZNF746 ZNF775	19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3
Entrez ID		51776	3507
HPRD ID		11791	00912
Ensembl ID		ENSG00000091436	ENSG00000211899
Uniprot IDs		D4Q8H0 Q9NYL2
PDB IDs		5HES 5X5O 6JUT 6JUU
Enriched GO Terms of Interacting Partners?
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