IGHM and JCHAIN

Number of citations of the paper that reports this interaction (PubMedID 1472500)
13

Data Source:
HPRD (in vitro)

		IGHM	JCHAIN
Description		immunoglobulin heavy constant mu	joining chain of multimeric IgA and IgM
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Single-stranded DNA Binding Antigen Binding Phosphatidylcholine Binding Immunoglobulin Receptor Binding Peptidoglycan Binding	Single-stranded DNA Binding Antigen Binding IgA Binding Protein-macromolecule Adaptor Activity Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding
	Biological Process	Adaptive Immune Response Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation, Classical Pathway Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	Retina Homeostasis Adaptive Immune Response Glomerular Filtration Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly
Pathways			Cell surface interactions at the vascular wall Scavenging of heme from plasma
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Systemic sclerosis ( 33069728)
Interacting Genes		19 interacting genes: APP CD22 CD79A CEP72 GADD45A GSK3B HPR HSPA5 JCHAIN MAP3K20 MAPKAPK3 PTK2 SH3GL2 SMN1 TK1 UBQLN4 UFD1 VPREB1 VPREB3	2 interacting genes: CD79A IGHM
Entrez ID		3507	3512
HPRD ID		00912	00991
Ensembl ID		ENSG00000211899	ENSG00000132465
Uniprot IDs			P01591
PDB IDs			6KXS 6LX3 6LXW 6UE7 6UE8 6UE9 6UEA 7K0C
Enriched GO Terms of Interacting Partners?
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