Description |
SUFU negative regulator of hedgehog signaling |
itchy E3 ubiquitin protein ligase |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Adult body size ( 32376654)
- Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359)
- Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359)
- Allergy ( 27182965)
- Autism spectrum disorder or schizophrenia ( 28540026)
- Body mass index ( 25673413 28448500)
- Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
- Body mass index in physically active individuals ( 28448500)
- Body shape index ( 34021172)
- Brain morphology (MOSTest) ( 32665545)
- Creatinine levels ( 29403010)
- Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
- Eosinophil counts ( 32888494)
- Estimated glomerular filtration rate ( 30604766)
- Glomerular filtration rate ( 29403010)
- Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
- Height ( 28552196)
- Hip circumference adjusted for BMI ( 34021172)
- Nickel levels ( 26025379)
- Optic disc size ( 31809533)
- Platelet count ( 32888494)
- Prostate cancer ( 23535732)
- Refractive error ( 32231278)
- Sum eosinophil basophil counts ( 27863252)
- Systolic blood pressure ( 30578418)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for body mass index ( 34021172 25673412)
- Waist-to-hip ratio adjusted for BMI ( 26426971)
- Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
- White blood cell count ( 29403010)
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Interacting Genes |
51 interacting genes:
ABI3
AKR1C1
BFSP2
BTRC
CRTC2
CRX
DISC1
EDA2R
FBXL17
FXR1
GLI1
GLI2
GLI3
GLIS3
HDX
HMGA1
HNRNPA1
ITCH
KRT27
KRT75
L3MBTL3
LAMTOR3
LCA5
LGALS3
LZTS1
MAGEL2
MEOX2
MID1IP1
NCOA3
PEX26
PIAS1
QPRT
RBPJ
RCN3
RNF19A
SAP18
SETDB1
SH3RF1
SLC41A3
STK36
STX19
TLE5
ZIC1
ZNF114
ZNF219
ZNF263
ZNF330
ZNF446
ZNF763
ZNF764
ZSCAN18
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108 interacting genes:
AGO2
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CEP250
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
ERBB4
EWSR1
FYN
GLIS3
GNAI2
HNRNPL
HNRNPUL1
JUN
JUNB
KPNB1
KSR1
LAPTM5
LITAF
LRRK1
MAP2K1
MAP2K4
MAPK8
MLANA
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NRAS
NUDT21
NUMB
PABPC1
PACSIN1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
PRRG4
RAF1
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
STAM2
SUFU
TAB1
TP63
TP73
TRPC4
TRPV1
TRPV4
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
WASL
WBP2
YWHAQ
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Entrez ID |
51684 |
83737 |
HPRD ID |
06124 |
07565 |
Ensembl ID |
ENSG00000107882
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ENSG00000078747
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Uniprot IDs |
A0A223LX15
Q9UMX1
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A0A590UJQ1
Q96J02
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PDB IDs |
1M1L
4BL8
4BL9
4BLA
4BLB
4BLD
4KM8
4KM9
4KMD
4KMH
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2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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