GET4 and GET3

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, two hybrid, two hybrid)

		GET4	GET3
Description		guided entry of tail-anchored proteins factor 4	guided entry of tail-anchored proteins factor 3, ATPase
Image
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex	Nucleoplasm Nucleolus Cytoplasm GET Complex Extracellular Exosome
	Molecular Function	Protein Binding Chaperone Binding	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Protein Insertion Into ER Membrane Cytoplasmic Sequestering Of Protein Tail-anchored Membrane Protein Insertion Into ER Membrane Maintenance Of Unfolded Protein Involved In ERAD Pathway	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		PR interval ( 32439900)
Interacting Genes		30 interacting genes: AKT1 ATP5PD BAG6 C1orf109 CAPNS1 CDKN1A CEP126 DNAAF5 DUSP21 EEF1G ENKD1 FBN1 FLYWCH2 GET3 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2	41 interacting genes: AGR2 APLN ASPH CACNA1A CAMLG CREB3L4 EMSY FAM209A FKBP7 GET4 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH STX5 SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		51608	439
HPRD ID		12909	03555
Ensembl ID		ENSG00000239857	ENSG00000198356
Uniprot IDs		Q7L5D6	O43681
PDB IDs		6AU8	6SO5
Enriched GO Terms of Interacting Partners?
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