SFMBT1 and PHC2

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
HPRD (two hybrid)

		SFMBT1	PHC2
Description		Scm like with four mbt domains 1	polyhomeotic homolog 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding
	Biological Process	Chromatin Organization Spermatogenesis Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Muscle Organ Development	Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Body shape index ( 34021172) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 29124443) General cognitive ability ( 29844566) Gout ( 33832965 31578528) Haemorrhoidal disease ( 33888516) Hand grip strength ( 29691431) Height ( 28552196 31562340 31217584) Hip circumference ( 28552196) Hyperuricemia ( 29124443) Intelligence (MTAG) ( 29326435) Mental health study participation (completed survey) ( 31263887) Multiple sclerosis ( 31604244) Schizophrenia ( 28991256 23974872) Serum uric acid levels ( 30993211 29124443 29403010) Type 2 diabetes (age of onset) ( 28060188) Urate levels ( 31985003 31578528 23263486) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pancreas volume ( 34128465) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		11 interacting genes: ACP1 CLNK FAM214B HOXB9 PHC1 PHC2 PSMA1 SCMH1 SPANXN2 SRPK1 ZCCHC10	79 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CRK CRKL CSNK2B DNMT1 DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB FXR1 FXR2 GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF3 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417
Entrez ID		51460	1912
HPRD ID		09539	10340
Ensembl ID		ENSG00000163935	ENSG00000134686
Uniprot IDs		A0A024R338 Q9UHJ3	A0A0A0MSI2 Q8IXK0
PDB IDs
Enriched GO Terms of Interacting Partners?
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