PHC2 and RWDD2B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		PHC2	RWDD2B
Description		polyhomeotic homolog 2	RWD domain containing 2B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Cellular_component
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription, DNA-templated	Biological_process
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood urea nitrogen levels ( 31152163 29403010) General risk tolerance (MTAG) ( 30643258) Pancreas volume ( 34128465) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		79 interacting genes: AEN AFG3L2 AP1M1 BMI1 BSDC1 BYSL C1orf109 CARD9 CRK CRKL CSNK2B DNMT1 DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB FXR1 FXR2 GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF3 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417	16 interacting genes: APP BRCA1 DDX19B DNM2 DVL3 EPB41 FAM163A GADD45G IKZF1 KIAA1958 KRT40 KRTAP10-7 MEOX2 PHC2 SRPK2 TRIM7
Entrez ID		1912	10069
HPRD ID		10340	10757
Ensembl ID		ENSG00000134686	ENSG00000156253
Uniprot IDs		A0A0A0MSI2 Q8IXK0	P57060
PDB IDs			2DAX
Enriched GO Terms of Interacting Partners?
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