ZNF593 and MAP3K20

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		ZNF593	MAP3K20
Description		zinc finger protein 593	mitogen-activated protein kinase kinase kinase 20
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Magnesium Ion Binding RNA Binding MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	DNA Damage Checkpoint Signaling Protein Phosphorylation Cytoskeleton Organization Cell Cycle JNK Cascade Cell Death Cell Differentiation P38MAPK Cascade Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Regulation Of Cell Cycle Limb Development Cellular Response To Gamma Radiation Positive Regulation Of Mitotic DNA Damage Checkpoint
Pathways
Drugs			Dasatinib Fostamatinib
Diseases
GWAS			Haemorrhoidal disease ( 33888516)
Interacting Genes		11 interacting genes: DDIT4L GPR3 LNX1 MAP3K20 MAP3K7 MAPK8IP2 PICK1 PIGV POLR1H RAB1A SRPK2	32 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP1 ZFP2 ZNF33A ZNF35 ZNF567 ZNF593 ZNF660 ZNF71 ZNF746 ZNF775
Entrez ID		51042	51776
HPRD ID		15866	11791
Ensembl ID		ENSG00000142684	ENSG00000091436
Uniprot IDs		O00488	D4Q8H0 Q9NYL2
PDB IDs		1ZR9 6LSS 6LU8	5HES 5X5O 6JUT 6JUU
Enriched GO Terms of Interacting Partners?
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