NOS2 and AP2B1

		NOS2	AP2B1
Description		nitric oxide synthase 2	adaptor related protein complex 2 subunit beta 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Vesicle Membrane Cortical Cytoskeleton Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynapse Glutamatergic Synapse
	Molecular Function	Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Circadian Rhythm Response To Bacterium Response To Hormone Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Cell Redox Homeostasis Negative Regulation Of Blood Pressure Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Positive Regulation Of Killing Of Cells Of Other Organism Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Xenobiotic Stimulus Regulation Of Cytokine Production Involved In Inflammatory Response	Kidney Development Ventricular Septum Development Intracellular Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Neuron Death Positive Regulation Of Protein Localization To Membrane
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Peroxisomal protein import Inhibition of nitric oxide production	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs		Arginine Citrulline Minocycline Miconazole Dexamethasone N,N-dimethylarginine 4R-Fluoro-N6-ethanimidoyl-L-lysine 3-Bromo-7-Nitroindazole N-[3-(aminomethyl)benzyl]acetamidine 7-Nitroindazole S-Ethylisothiourea Thiocoumarin N-omega-propyl-L-arginine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Imidazole N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Thiocitrulline L-erythro-7,8-dihydrobiopterin 5-Nitroindazole KD7040 Fenoxaprop-ethyl Pimagedine 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE Triflusal Levamlodipine Dipyrithione Dexamethasone acetate
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Ankylosing spondylitis ( 23749187 30946743) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Cutaneous psoriasis ( 26626624) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953189 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 32888494 27863252) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		14 interacting genes: AATF ACTB ACTN4 AP2B1 CAV1 CSF3 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC	64 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B C2CD6 CCDC187 CLINT1 COL3A1 DHX58 DNAJC5 EFTUD2 EGFR FMNL2 GPANK1 GTF2I HIP1 HSPB1 ITSN1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 LRRFIP1 MEA1 MLH1 NECAP2 NEU4 NOS2 NUP54 PIP5K1C PKP1 POM121 PSORS1C2 RAPGEF3 RIBC2 SERTAD2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC VSIG4
Entrez ID		4843	163
HPRD ID		01225	03015
Ensembl ID		ENSG00000007171	ENSG00000006125
Uniprot IDs		P35228	A0A140VJE8 P63010 Q96EL6
PDB IDs		1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5TP6 5XN3 6JWM 6JWN 6KEY	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI
Enriched GO Terms of Interacting Partners?
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