HiPPIP
Home
About
SZ Genes
People
Help
Advanced Search
AP2B1 and ARRB1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
86
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid, in vitro)
AP2B1
ARRB1
Description
adaptor related protein complex 2 subunit beta 1
arrestin beta 1
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Membrane
AP-2 Adaptor Complex
Clathrin Adaptor Complex
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Endolysosome Membrane
Clathrin-coated Endocytic Vesicle
Postsynapse
Glutamatergic Synapse
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Endosome
Cytosol
Plasma Membrane
Clathrin-coated Pit
Postsynaptic Density
Basolateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle Membrane
Pseudopodium
Cytoplasmic Vesicle
Dendritic Spine
Postsynaptic Membrane
Molecular Function
Signal Sequence Binding
Protein Binding
Clathrin Binding
Clathrin Adaptor Activity
Protein-containing Complex Binding
G Protein-coupled Receptor Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Enzyme Inhibitor Activity
GTPase Activator Activity
Insulin-like Growth Factor Receptor Binding
Protein Binding
Transcription Factor Binding
Estrogen Receptor Binding
Ubiquitin Protein Ligase Binding
Alpha-1A Adrenergic Receptor Binding
Alpha-1B Adrenergic Receptor Binding
Angiotensin Receptor Binding
Follicle-stimulating Hormone Receptor Binding
V2 Vasopressin Receptor Binding
AP-2 Adaptor Complex Binding
Clathrin Adaptor Activity
Transmembrane Transporter Binding
Protein Phosphorylated Amino Acid Binding
Arrestin Family Protein Binding
Biological Process
Kidney Development
Ventricular Septum Development
Intracellular Protein Transport
Vesicle-mediated Transport
Aorta Development
Positive Regulation Of Endocytosis
Clathrin Coat Assembly
Coronary Vasculature Development
Clathrin-dependent Endocytosis
Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Neuron Death
Positive Regulation Of Protein Localization To Membrane
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
G Protein-coupled Receptor Internalization
Positive Regulation Of Receptor Internalization
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Protein Transport
Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of GTPase Activity
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Histone Acetylation
Follicle-stimulating Hormone Signaling Pathway
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Histone H4 Acetylation
Pathways
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Activated NOTCH1 Transmits Signal to the Nucleus
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
Activation of SMO
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Diseases
GWAS
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Chronotype (
30696823
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
)
Mean platelet volume (
22139419
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Platelet count (
22139419
27863252
)
Platelet distribution width (
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Obstructive sleep apnea trait (average respiratory event duration) (
26977737
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
64 interacting genes:
-
ACVR1
AFF4
AP1M1
AP1M2
AP2A2
AP2M1
AP2S1
APC
ARRB1
ATM
ATP23
ATP6V1G1
BUB1
BUB1B
C2CD6
CCDC187
CLINT1
COL3A1
DHX58
DNAJC5
EFTUD2
EGFR
FMNL2
GPANK1
GTF2I
HIP1
HSPB1
ITSN1
KANK2
KIAA0408
KPNA2
LDLRAP1
LONRF1
LRRFIP1
MEA1
MLH1
NECAP2
NEU4
NOS2
NUP54
PIP5K1C
PKP1
POM121
PSORS1C2
RAPGEF3
RIBC2
SERTAD2
SLC25A6
SLC2A8
SMAD4
SMURF1
SNAP91
TENT5C
TERF2IP
TEX12
TGFBR1
TGFBR2
THAP1
TUBGCP4
TXN2
U2AF1
UBC
VSIG4
55 interacting genes:
ADH6
ADRB1
ADRB2
AGTR1
AP2B1
ARF6
BAG1
BTK
C5AR1
CCR5
CDC42
CLTC
CRHR1
CSK
CXCR2
CYTH2
DVL1
DVL2
FGR
FLNA
GNMT
GPR50
GRK2
GSK3B
HCK
HCRTR1
JUN
LIMK1
MAP2K3
MAP2K4
MAPK1
MAPK10
MAPK3
MAPK9
MDM2
NEK6
NFKBIA
NSF
OPRD1
PDE4D
PIK3R2
POT1
POU2F1
PRDM16
PRKN
PTH1R
PTHLH
RALGDS
RPL15
SASH1
SLC9A5
SREBF2
STAM
TRHR
ZBTB43
Entrez ID
163
408
HPRD ID
03015
00146
Ensembl ID
ENSG00000006125
ENSG00000137486
Uniprot IDs
A0A140VJE8
P63010
Q96EL6
B7Z1Q3
P49407
PDB IDs
1E42
2G30
2IV8
2IV9
2JKR
2JKT
2VGL
2XA7
4UQI
5M5R
6QH5
6QH6
6QH7
6URI
6YAE
6YAF
6YAH
6YAI
2IV8
6PWC
6TKO
6UP7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?