AP2B1 and AFF4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		AP2B1	AFF4
Description		adaptor related protein complex 2 subunit beta 1	AF4/FMR2 family member 4
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynapse Glutamatergic Synapse	Fibrillar Center Nucleoplasm Transcription Elongation Factor Complex Super Elongation Complex Transcriptionally Active Chromatin
	Molecular Function	Signal Sequence Binding Protein Binding Clathrin Binding Clathrin Adaptor Activity Protein-containing Complex Binding	Protein Binding
	Biological Process	Kidney Development Ventricular Septum Development Intracellular Protein Transport Vesicle-mediated Transport Aorta Development Positive Regulation Of Endocytosis Clathrin Coat Assembly Coronary Vasculature Development Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Neuron Death Positive Regulation Of Protein Localization To Membrane	Spermatid Development Regulation Of Gene Expression
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 22139419 32888494 27863252) Mean reticulocyte volume ( 32888494) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Asthma ( 31619474) Body shape index ( 34021172) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		64 interacting genes: - ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP23 ATP6V1G1 BUB1 BUB1B C2CD6 CCDC187 CLINT1 COL3A1 DHX58 DNAJC5 EFTUD2 EGFR FMNL2 GPANK1 GTF2I HIP1 HSPB1 ITSN1 KANK2 KIAA0408 KPNA2 LDLRAP1 LONRF1 LRRFIP1 MEA1 MLH1 NECAP2 NEU4 NOS2 NUP54 PIP5K1C PKP1 POM121 PSORS1C2 RAPGEF3 RIBC2 SERTAD2 SLC25A6 SLC2A8 SMAD4 SMURF1 SNAP91 TENT5C TERF2IP TEX12 TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 UBC VSIG4	11 interacting genes: AP2B1 CCNT1 CDK9 ELL2 GOLGA2 LRRK2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2
Entrez ID		163	27125
HPRD ID		03015	09187
Ensembl ID		ENSG00000006125	ENSG00000072364
Uniprot IDs		A0A140VJE8 P63010 Q96EL6	Q9UHB7
PDB IDs		1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7 4UQI 5M5R 6QH5 6QH6 6QH7 6URI 6YAE 6YAF 6YAH 6YAI	4IMY 4OGR 4OR5 5JW9 5L1Z 6CYT 6K7P 6KN5 6R80
Enriched GO Terms of Interacting Partners?
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