NOS2 and CSF3

		NOS2	CSF3
Description		nitric oxide synthase 2	colony stimulating factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Vesicle Membrane Cortical Cytoskeleton Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Lysosomal Lumen Endocytic Vesicle Lumen
	Molecular Function	Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Circadian Rhythm Response To Bacterium Response To Hormone Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Cell Redox Homeostasis Negative Regulation Of Blood Pressure Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Positive Regulation Of Killing Of Cells Of Other Organism Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Xenobiotic Stimulus Regulation Of Cytokine Production Involved In Inflammatory Response	Immune Response Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Response To Ethanol Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Peroxisomal protein import Inhibition of nitric oxide production	Other interleukin signaling Interleukin-10 signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling
Drugs		Arginine Citrulline Minocycline Miconazole Dexamethasone N,N-dimethylarginine 4R-Fluoro-N6-ethanimidoyl-L-lysine 3-Bromo-7-Nitroindazole N-[3-(aminomethyl)benzyl]acetamidine 7-Nitroindazole S-Ethylisothiourea Thiocoumarin N-omega-propyl-L-arginine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Imidazole N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Thiocitrulline L-erythro-7,8-dihydrobiopterin 5-Nitroindazole KD7040 Fenoxaprop-ethyl Pimagedine 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE Triflusal Levamlodipine Dipyrithione Dexamethasone acetate
Diseases
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Ankylosing spondylitis ( 23749187 30946743) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Cutaneous psoriasis ( 26626624) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory skin disease ( 25574825) Psoriasis ( 25903422 20953189 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624)	Asthma ( 31619474) Bipolar disorder ( 31043756) Composite immunoglobulin trait (IgA x IgG) ( 28628107) Creatine kinase levels ( 29403010) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mitochondrial DNA copy number ( 30704525) Myeloid white cell count ( 27863252) Neutrophil count ( 25096241 20172861 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Rheumatoid arthritis ( 30423114 24390342) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 32888494 20139978 27863252 21738480 28158719) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		14 interacting genes: AATF ACTB ACTN4 AP2B1 CAV1 CSF3 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC	9 interacting genes: CDK2 CSF3R ELANE HDAC6 NOS2 NQO2 PARVG SLFN11 TBX3
Entrez ID		4843	1440
HPRD ID		01225	00736
Ensembl ID		ENSG00000007171	ENSG00000108342
Uniprot IDs		P35228	P09919 Q6FH65 Q8N4W3
PDB IDs		1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5TP6 5XN3 6JWM 6JWN 6KEY	1CD9 1GNC 1PGR 1RHG 2D9Q 5GW9 5ZO6
Enriched GO Terms of Interacting Partners?
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