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ATM and NFE2L2
Number of citations of the paper that reports this interaction (PubMedID
32911434
)
1
Data Source:
BioGRID
(two hybrid)
ATM
NFE2L2
Description
ATM serine/threonine kinase
nuclear factor, erythroid 2 like 2
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Peroxisomal Matrix
Centrosome
Cytosol
Cytoplasmic Vesicle
Intracellular Membrane-bounded Organelle
DNA Repair Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Protein-DNA Complex
Molecular Function
DNA Binding
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
1-phosphatidylinositol-3-kinase Activity
Identical Protein Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
DNA Damage Checkpoint Signaling
Telomere Maintenance
Pre-B Cell Allelic Exclusion
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Spindle Assembly Checkpoint Signaling
Mitotic G2 DNA Damage Checkpoint Signaling
Reciprocal Meiotic Recombination
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Ionizing Radiation
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Phosphatidylinositol-3-phosphate Biosynthetic Process
Peptidyl-serine Autophosphorylation
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Regulation Of Cell Cycle
Regulation Of Telomerase Activity
Histone MRNA Catabolic Process
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Cellular Response To Nitrosative Stress
Cellular Senescence
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of TORC1 Signaling
Negative Regulation Of Telomere Capping
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Aging
Response To Lithium Ion
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Positive Regulation Of Glutathione Biosynthetic Process
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53
Meiotic recombination
Pexophagy
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
ROS sensing by NFE2L2
ROS sensing by NFE2L2
Regulation of HMOX1 expression and activity
Heme signaling
Drugs
Caffeine
Diseases
GWAS
Alzheimer's disease (late onset) (
28714976
)
Cutaneous malignant melanoma (
32341527
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Gastric adenocarcinoma (histologically verified) (
26098866
)
Gastric cancer (
26098866
)
Leukocyte telomere length (
32109421
31171785
)
Lymphocyte counts (
32888494
)
Mean reticulocyte volume (
32888494
)
Melanoma (
21983787
28212542
)
Myeloproliferative neoplasms (
33057200
)
Nevus count or cutaneous melanoma (
32341527
30429480
)
Nonunion in individuals with fractures (
30680360
)
Prostate cancer (
29892016
)
Red blood cell count (
29403010
)
Refractive error (
32231278
)
Renal cell carcinoma (
28598434
)
Response to metformin in type 2 diabetes (glycemic) (
21186350
)
Rheumatoid arthritis (
30423114
24390342
)
Sum eosinophil basophil counts (
27863252
)
Uterine fibroids (
30194396
)
Body shape index (
34021172
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
109 interacting genes:
AATF
ABL1
ACTL6B
AP1B1
AP2B1
AP3B1
AP3B2
ARHGAP20
ATR
BCAS3
BCL10
BCO2
BRCA1
BRCA2
CD9
CDC6
CDKN2C
CHD4
CHEK1
CHEK2
COPS5
CREB1
CRX
CRYAB
CSNK1D
CXXC5
DAXX
DCAF1
DCLRE1C
DDX1
DYRK2
E2F1
E4F1
EEF1E1
EIF3E
EIF4EBP1
ERRFI1
ESRRG
EXO1
FANCD2
FECH
FOXO3
H2AX
HIF1A
HINT1
HSPA8
HSPB2
IL24
KAT5
KAT8
LIG4
MAP1S
MCM2
MCPH1
MDC1
MDM2
MDM4
MRE11
MT-ND4
MTA3
NBN
NFE2L2
NR4A1
NREP
NSD3
OSGIN1
PAN2
PARP1
PEX5
PGR
POLR2A
POLR2F
PPP2R5C
PRKDC
PTCH1
PTS
RAD17
RAD51
RAD9A
RANBP9
RASSF1
RBBP8
RHEB
RNF20
RNF40
RPA1
RPA2
SMC1A
SPSB1
STK11
TCL1A
TELO2
TERF1
TERF2
TFF1
TIPARP
TOP1
TOPBP1
TP53
TP53BP1
TRAF6
TREX1
TRIM29
UCHL3
WRN
XPA
XRCC5
ZEB1
ZNF821
80 interacting genes:
APEX1
ARFIP2
ARPC2
ATF3
ATF4
ATM
BPTF
BRPF1
BRPF3
BTRC
CASP1
CASP3
CDH1
CEBPG
CERS2
CFAP299
CHD6
COPS7A
CREB3
CREBBP
CREBL2
CREBZF
DDIT3
EIF2AK3
EIF3J
ELF1
ELF3
ELF4
ELF5
ELK1
ETV1
ETV4
ETV6
FBXW11
FOSB
FOSL2
GSK3B
HNRNPR
IRF2
JUN
JUND
KDM1A
KEAP1
KPNA2
KPNA3
KPNA4
LEF1
MAFF
MAFG
MAFK
MAP2K6
MAPK7
MAPK8
NCOR2
NFAT5
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
REL
RELA
SMAD1
SP140
SPIC
STAT3
SUMO1
SUMO2
TADA2A
TBP
TEF
TNNT1
TRIM24
UBE2E2
WAC
ZBTB24
ZNF396
Entrez ID
472
4780
HPRD ID
06347
02732
Ensembl ID
ENSG00000149311
ENSG00000116044
Uniprot IDs
A0A024R3C7
Q13315
Q16236
PDB IDs
5NP0
5NP1
6HKA
6K9K
6K9L
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
Enriched GO Terms of Interacting Partners
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