MIP and FOXA2

Number of citations of the paper that reports this interaction (PubMedID 12642491)
18

Data Source:
HPRD (in vitro)

		MIP	FOXA2
Description		major intrinsic protein of lens fiber	forkhead box A2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Integral Component Of Membrane Apical Plasma Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Water Transport Visual Perception Positive Regulation Of Cell Adhesion Response To Stimulus Protein Homotetramerization Transmembrane Transport Gap Junction-mediated Intercellular Transport	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Negative Regulation Of Epithelial To Mesenchymal Transition Cell Differentiation Regulation Of Blood Coagulation Endocrine Pancreas Development Negative Regulation Of Glucokinase Activity Positive Regulation Of Embryonic Development Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Response To Interleukin-6 Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Gastrulation Negative Regulation Of Detection Of Glucose
Pathways		Passive transport by Aquaporins	Regulation of gene expression in beta cells
Drugs		B-nonylglucoside
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874) Axial length ( 24144296) Serum metabolite levels ( 33031748)	Adolescent idiopathic scoliosis ( 25784220) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Body size at age 10 ( 32376654) Fasting blood glucose ( 33842983 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting plasma glucose ( 25187374 20152958) Gout ( 22179738) Hypothyroidism ( 27182965) Male-pattern baldness ( 22693459 27182965) Monobrow ( 27182965) Type 2 diabetes ( 30054458 32499647) Vitamin D levels ( 26704534)
Interacting Genes		47 interacting genes: AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1	9 interacting genes: EN2 GSC HOXA5 LHX1 MIP NCOA1 ONECUT1 OTX2 TLE1
Entrez ID		4284	3170
HPRD ID		01098	02618
Ensembl ID		ENSG00000135517	ENSG00000125798
Uniprot IDs		P30301	B0ZTD4 Q9Y261
PDB IDs			5X07
Enriched GO Terms of Interacting Partners?
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