M6PR and KTN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		M6PR	KTN1
Description		mannose-6-phosphate receptor, cation dependent	kinectin 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding	RNA Binding Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes	Microtubule-based Movement Protein Transport
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)	Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)
Interacting Genes		13 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4 TMPRSS15	30 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 IKBKE INPP5E KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 MFSD14B PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG SGTA SIRPA STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I
Entrez ID		4074	3895
HPRD ID		01106	02661
Ensembl ID		ENSG00000003056	ENSG00000126777
Uniprot IDs		F5GX30 P20645	A0A024R663 Q86UP2
PDB IDs		1JUQ
Enriched GO Terms of Interacting Partners?
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