M6PR and TMPRSS15

		M6PR	TMPRSS15
Description		mannose-6-phosphate receptor, cation dependent	transmembrane serine protease 15
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GO Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Brush Border Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes	Proteolysis Endocytosis
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)	Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		13 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4 TMPRSS15	7 interacting genes: GABPA GART HUNK M6PR RPL19 RPS4Y1 SPINK1
Entrez ID		4074	5651
HPRD ID		01106	05972
Ensembl ID		ENSG00000003056	ENSG00000154646
Uniprot IDs		F5GX30 P20645	P98073
PDB IDs		1JUQ	4DGJ 6ZOV
Enriched GO Terms of Interacting Partners?
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