M6PR and GGA2

Number of citations of the paper that reports this interaction (PubMedID 11387475)
134

Data Source:
HPRD (in vitro, two hybrid)

		M6PR	GGA2
Description		mannose-6-phosphate receptor, cation dependent	golgi associated, gamma adaptin ear containing, ARF binding protein 2
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin-coated Vesicle Early Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes	Intracellular Protein Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	TBC/RABGAPs Amyloid fiber formation
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)
Interacting Genes		13 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4 TMPRSS15	36 interacting genes: ADRA2B AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC FBXO7 GGA1 GGA3 GOLGA2 HGS HTT IGF2R LRP3 M6PR MAP3K1 MEMO1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TRIM23 VPS18
Entrez ID		4074	23062
HPRD ID		01106	09347
Ensembl ID		ENSG00000003056	ENSG00000103365
Uniprot IDs		F5GX30 P20645	Q9UJY4
PDB IDs		1JUQ	1MHQ
Enriched GO Terms of Interacting Partners?
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