AFF3 and IL18RAP

		AFF3	IL18RAP
Description		AF4/FMR2 family member 3	interleukin 18 receptor accessory protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Double-stranded DNA Binding DNA-binding Transcription Factor Activity	Protein Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis	Inflammatory Response Immune Response Cell Population Proliferation Interleukin-18-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide
Pathways			Interleukin-18 signaling
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 27798627) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634) Autoimmune traits (pleiotropy) ( 30572963) Body shape index ( 34021172) Cannabis dependence symptom count ( 27028160) Celiac disease ( 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 34187846 31527586) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Household income ( 27818178) Household income (MTAG) ( 31844048) IgG levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Non-albumin protein levels ( 29403010) Number of children ever born ( 27798627) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252) Refractive astigmatism ( 30306274) Regular attendance at a religious group ( 29970889) Rheumatoid arthritis ( 30423114 24782177 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 29403010) Triglyceride levels ( 34074324) Type 1 diabetes ( 25751624 17554260 34127860) Type 1 diabetes nephropathy ( 23028342) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 28240269) Celiac disease ( 22057235 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: DPP8 GPR137B IL18R1 IL18RAP ST6GAL2	5 interacting genes: AFF3 APP CD48 IL18 TRIM54
Entrez ID		3899	8807
HPRD ID		03272	05147
Ensembl ID		ENSG00000144218	ENSG00000115607
Uniprot IDs		P51826 Q8NAP7	O95256
PDB IDs			3WO4 6KN9
Enriched GO Terms of Interacting Partners?
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