IL18RAP and CD48

Number of citations of the paper that reports this interaction (PubMedID 15760905)
8

Data Source:
HPRD (in vivo)

		IL18RAP	CD48
Description		interleukin 18 receptor accessory protein	CD48 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Interleukin-18 Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Antigen Binding Protein Binding Signaling Receptor Activity
	Biological Process	Inflammatory Response Immune Response Cell Population Proliferation Interleukin-18-mediated Signaling Pathway Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Hydrogen Peroxide	Regulation Of Adaptive Immune Response Defense Response T Cell Activation
Pathways		Interleukin-18 signaling	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 23817571) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 28240269) Celiac disease ( 22057235 20190752 18311140) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Extranodal natural killer T-cell lymphoma (nasal type) ( 31879220) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Systemic lupus erythematosus ( 28714469)	Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		5 interacting genes: AFF3 APP CD48 IL18 TRIM54	20 interacting genes: ACKR1 BRIX1 C1orf68 CD2 CD244 CD247 DIO1 E2F2 EEF1D EFNA1 EFNA3 FYN GNAI3 IL18R1 IL18RAP LCK LY9 MAST2 OAZ3 P4HA1
Entrez ID		8807	962
HPRD ID		05147	00177
Ensembl ID		ENSG00000115607	ENSG00000117091
Uniprot IDs		O95256	A0A087X1S7 P09326
PDB IDs		3WO4 6KN9	2EDO
Enriched GO Terms of Interacting Partners?
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