AFF3 and GPR137B

		AFF3	GPR137B
Description		AF4/FMR2 family member 3	G protein-coupled receptor 137B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex	Lysosomal Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Double-stranded DNA Binding DNA-binding Transcription Factor Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis	Autophagy Regulation Of Autophagy Regulation Of Macrophage Activation Regulation Of GTPase Activity Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of TORC1 Signaling
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 27798627) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634) Autoimmune traits (pleiotropy) ( 30572963) Body shape index ( 34021172) Cannabis dependence symptom count ( 27028160) Celiac disease ( 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Extremely high intelligence ( 29520040) Gastroesophageal reflux disease ( 34187846 31527586) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Height ( 31217584) Hip circumference adjusted for BMI ( 34021172) Household income ( 27818178) Household income (MTAG) ( 31844048) IgG levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Non-albumin protein levels ( 29403010) Number of children ever born ( 27798627) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252) Refractive astigmatism ( 30306274) Regular attendance at a religious group ( 29970889) Rheumatoid arthritis ( 30423114 24782177 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 29403010) Triglyceride levels ( 34074324) Type 1 diabetes ( 25751624 17554260 34127860) Type 1 diabetes nephropathy ( 23028342) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Diastolic blood pressure ( 27841878) Metabolite levels ( 23823483) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		5 interacting genes: DPP8 GPR137B IL18R1 IL18RAP ST6GAL2	4 interacting genes: AFF3 APP NLGN4X TRIM32
Entrez ID		3899	7107
HPRD ID		03272	06878
Ensembl ID		ENSG00000144218	ENSG00000077585
Uniprot IDs		P51826 Q8NAP7	O60478
PDB IDs
Enriched GO Terms of Interacting Partners?
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