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KIT and PLCG1
Number of citations of the paper that reports this interaction (PubMedID
7536744
)
3
Data Source:
HPRD
(in vivo)
KIT
PLCG1
Description
KIT proto-oncogene, receptor tyrosine kinase
phospholipase C gamma 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Receptor Complex
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Molecular Function
Protease Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Glutamate Receptor Binding
Calcium-dependent Phospholipase C Activity
Biological Process
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Inflammatory Response
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Spermatogenesis
Spermatid Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Visual Learning
Male Gonad Development
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Actin Cytoskeleton Reorganization
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Pigmentation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Tongue Development
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Somatic Stem Cell Division
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Cellular Response To Thyroid Hormone Stimulus
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
In Utero Embryonic Development
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Cell Migration
Calcium-mediated Signaling
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
ABT-869
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Diseases
GWAS
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
29403010
28017375
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
29403010
28453575
28017375
)
Mean corpuscular volume (
29403010
28453575
20139978
28017375
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
32203549
31928498
)
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
93 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KDR
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
111 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
Entrez ID
3815
5335
HPRD ID
01287
01398
Ensembl ID
ENSG00000157404
ENSG00000124181
Uniprot IDs
A0A0U2N547
P10721
P19174
Q4LE43
Q9UFY1
PDB IDs
1PKG
1QZJ
1QZK
1R01
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
1HSQ
2HSP
4EY0
4FBN
Enriched GO Terms of Interacting Partners
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