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PLCG1 and TEC
Number of citations of the paper that reports this interaction (PubMedID
10823839
)
4
Data Source:
HPRD
(in vitro)
PLCG1
TEC
Description
phospholipase C gamma 1
tec protein tyrosine kinase
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Lamellipodium
Ruffle Membrane
Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Cytosol
Cytoskeleton
Plasma Membrane
Molecular Function
Phosphatidylinositol Phospholipase C Activity
Phospholipase C Activity
Neurotrophin TRKA Receptor Binding
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Glutamate Receptor Binding
Calcium-dependent Phospholipase C Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phospholipid Binding
Metal Ion Binding
Biological Process
In Utero Embryonic Development
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Epidermal Growth Factor Receptor Signaling Pathway
Phospholipid Catabolic Process
Positive Regulation Of Epithelial Cell Migration
Cell Migration
Calcium-mediated Signaling
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Phosphatidylinositol Metabolic Process
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Apoptotic Process
Adaptive Immune Response
Protein Phosphorylation
Integrin-mediated Signaling Pathway
Regulation Of Platelet Activation
Peptidyl-tyrosine Phosphorylation
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Tissue Regeneration
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Pathways
ISG15 antiviral mechanism
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
PLC-gamma1 signalling
Synthesis of IP3 and IP4 in the cytosol
Downstream signal transduction
Signaling by ALK
Generation of second messenger molecules
Role of phospholipids in phagocytosis
Role of phospholipids in phagocytosis
PECAM1 interactions
EGFR interacts with phospholipase C-gamma
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Role of second messengers in netrin-1 signaling
VEGFR2 mediated cell proliferation
VEGFR2 mediated cell proliferation
Constitutive Signaling by EGFRvIII
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PLCG1
FCGR3A-mediated IL10 synthesis
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by ALK fusions and activated point mutants
Signaling by SCF-KIT
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs
Fostamatinib
Zanubrutinib
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Birth weight (
31043758
)
Brain morphology (MOSTest) (
32665545
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
LDL cholesterol levels (
32203549
)
Major depressive disorder (
27479909
)
Male-pattern baldness (
28196072
)
Refractive error (
32231278
)
Triglyceride levels (
32203549
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Crohn's disease (
23128233
)
Metabolite levels (
23823483
)
Pulse pressure (
27841878
)
Rheumatoid arthritis (
30423114
24390342
)
Systolic blood pressure (
27841878
)
Interacting Genes
111 interacting genes:
ABL1
AGAP2
AGTR1
AKT1
ALK
AR
ARHGAP32
ARHGEF5
AXL
BAG3
BCR
BLNK
BTK
CBL
CD22
CD28
CTSS
DAB1
DAPP1
DDR1
DGKZ
DNM1
DOK1
EEF1A1
EGFR
EPHB2
EPOR
ERBB2
ERBB3
ERBB4
FGFR1
FGFR2
FGFR4
FLT1
FYN
GAB1
GAB2
GHR
GIT1
GRAP
GRB2
GRIN1
GRIN2A
GRIN2B
GSN
GTF2H1
HCK
INPP5D
INSR
IRS2
ITK
KDR
KHDRBS1
KIT
LAT
LAT2
LCK
LCP2
LIFR
LYN
MAPT
MET
MST1R
NCAM1
NCK1
NPM1
NTRK1
NTRK2
NTRK3
PAK1
PDGFRA
PDGFRB
PECAM1
PICALM
PITPNA
PKN2
PLD2
PRKD1
PRMT8
PTK2
PTPN11
PTPRJ
RACK1
RET
RHOA
RHOU
SELE
SH2D2A
SH3BP2
SHB
SHC1
SNAP91
SOCS7
SOS1
SOS2
SRC
SYK
SYN1
SYNCRIP
TEC
TNK1
TRIM14
TRPC3
TRPM7
TUB
USO1
VAV1
VAV3
VIL1
WAS
ZAP70
42 interacting genes:
ARHGAP6
ARHGEF12
BMX
BTK
COMMD8
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FBXO7
GAB1
GABRB1
GNA12
IKBKG
JAK1
JAK2
KIT
LRRK1
LYN
MET
OTUD4
PIK3R1
PIK3R2
PIK3R3
PIP4K2A
PIP5K1A
PLCG1
PLCG2
PLK4
PRLR
PRRG4
PTPN18
PTPN21
SHC1
SOCS1
STAP1
TP53
TXK
VAV1
WAS
Entrez ID
5335
7006
HPRD ID
01398
02786
Ensembl ID
ENSG00000124181
ENSG00000135605
Uniprot IDs
P19174
Q4LE43
Q9UFY1
P42680
PDB IDs
1HSQ
2HSP
4EY0
4FBN
2LUL
Enriched GO Terms of Interacting Partners
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