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KIT and LYN
Number of citations of the paper that reports this interaction (PubMedID
9341198
)
46
Data Source:
HPRD
(in vitro, in vivo)
KIT
LYN
Description
KIT proto-oncogene, receptor tyrosine kinase
LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Receptor Complex
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Lysosomal Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Postsynaptic Density
Mitochondrial Crista
Endocytic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Integrin Alpha2-beta1 Complex
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Molecular Function
Protease Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
SH3 Domain Binding
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Transmembrane Transporter Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Scaffold Protein Binding
Phosphorylation-dependent Protein Binding
Biological Process
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Inflammatory Response
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Spermatogenesis
Spermatid Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Visual Learning
Male Gonad Development
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Actin Cytoskeleton Reorganization
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Pigmentation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Tongue Development
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Somatic Stem Cell Division
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Cellular Response To Thyroid Hormone Stimulus
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To Sterol Depletion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Response To Organic Cyclic Compound
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Extracellular Stimulus
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
ABT-869
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
Diseases
GWAS
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
29403010
28017375
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
29403010
28453575
28017375
)
Mean corpuscular volume (
29403010
28453575
20139978
28017375
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
32203549
31928498
)
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
32888494
27863252
)
Interacting Genes
93 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KDR
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
137 interacting genes:
ACTB
ADAM15
AGXT
AR
ARFGEF1
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
CLCF1
COASY
CREBBP
CRH
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
KLHL41
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NEK7
NMT1
NPHS1
PAG1
PAK2
PDCD4
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PNMA2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PRRG4
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SGK3
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SOCS1
SPHK1
SPHK2
SRC
STAT3
SYK
TEC
TERF1
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPA1
TRPV4
TYK2
UBB
UHRF2
UNC119
Entrez ID
3815
4067
HPRD ID
01287
01301
Ensembl ID
ENSG00000157404
ENSG00000254087
Uniprot IDs
A0A0U2N547
P10721
A8K379
P07948
Q6NUK7
PDB IDs
1PKG
1QZJ
1QZK
1R01
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
1W1F
1WA7
3A4O
5XY1
6NMW
Enriched GO Terms of Interacting Partners
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