ACAT1 and PTPRF

Number of citations of the paper that reports this interaction (PubMedID 25458010)
29

Data Source:
BioGRID (two hybrid)

		ACAT1	PTPRF
Description		acetyl-CoA acetyltransferase 1	protein tyrosine phosphatase receptor type F
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Enzyme Binding Potassium Ion Binding Identical Protein Binding Coenzyme A Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding
	Biological Process	Liver Development Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Brain Development Response To Hormone Response To Organic Cyclic Compound Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies	Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
Drugs		Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)	Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444 33495439) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Disruptive behavior disorder and attention deficit hyperactivity disorder ( 33495439) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: AGXT CXCR4 PDP1 PEX7 PTPRF	68 interacting genes: ABCG1 ACAN ACAT1 ACTB ALDH1A1 ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INPP5B INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB LINC01587 MPL MYCBP NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B UROD VCAN YBX1 ZMPSTE24 ZNF512B
Entrez ID		38	5792
HPRD ID		01946	01552
Ensembl ID		ENSG00000075239	ENSG00000142949
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 P24752	G1UI20 P10586
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY	1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW
Enriched GO Terms of Interacting Partners?
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